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Although in slightly different ways, both GLA and DHA decreased the production of aldosterone. In the GLA study the aldosterone/renin anti inflammatory herb ratio was significantly lower in the borage oil group than in the control group given sesame oil. In the DHA anti inflammatory herb study aldosterone was significantly lowered (33%) compared to the control group fed a diet anti inflammatory herb containing corn/soybean oil. A remarkable reduction of the systolic blood pressure was also seen in both studies. In the borage oil group the decrease was 12 mmHg after three weeks, and in the DHA study the blood pressure was 34 mmHg lower on an average after six weeks. The observations in these studies suggested that borage oil (GLA) inhibits the adrenal responsiveness to angiotensin II through diminished angiotensin receptor activity in aldosterone producing cells.
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