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None of the serious adverse events that were reported associated omega-3 fatty acid consumption with events such as essentialfatty acids / phospholipids death, life-threatening illness, or significant disability or handicap, although two studies reported that some important bleeding occurred with fish oil combined with aspirin or warfarin.39,40 Return to Contents Discussion Overall, essentialfatty acids / phospholipids a number of studies offer evidence to support the hypothesis that fish, fish oil, or ALA supplement consumption reduces all-cause mortality and various CVD outcomes, although the evidence is strongest for fish or fish oil. The essentialfatty acids / phospholipids overall methodological quality of the studies included in this evidence review was graded as good for fish oil (EPA+DHA), but RCT data for ALA was poor. The adverse events due to fish oil or ALA supplement consumption appear to be minor.
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