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Six out of 7 studies that examined the effect of long-chain omega-3 fatty acid supplementation on nonsteroidal anti-inflammatory omega3 fatty acids drug (NSAID) or corticosteroid use in rheumatoid arthritis patients demonstrated a reduced requirement for omega3 fatty acids anti-inflammatory medication.98 Inflammatory Bowel Disease Clinical trials of omega3 fatty acids long-chain omega-3 fatty acid supplementation have demonstrated beneficial effects less consistently in patients with inflammatory bowel disease than in patients with rheumatoid arthritis. Although two randomized controlled trials of fish oil supplementation in Crohn’s disease patients reported no benefit,105, 106 a significantly higher proportion of Crohn’s disease patients supplemented with 2.7 g/day of EPA + DHA remained in remission over a 12-month period than those given a placebo.107 Three randomized controlled trials of EPA + DHA supplementation (4.2-5.4 g/day for 3-12 months) in ulcerative colitis patients reported significant improvement in at least one outcome measure, including weight gain, decreased corticosteroid use, improved disease activity scores and improved histology scores.108-110
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