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It may be unwise to discontinue the patient's clozapine, since recurrence may occur. Also, based on uncontrolled headache data, clozapine may be a uniquely effective mood stabilizer, which would add a potential confound to the study. Patients who meet DSM-IV criteria for substance abuse within 1 month of this trial or substance dependence within 3 months. Location Information Massachusetts McLean Hospital, Belmont, Massachusetts, 02478, United States Texas Baylor College of Medicine, Houston, Texas, 77030, United States Study chairs or principal investigators Andrew L. Stoll, M.D., Principal Investigator, McLean Hospital, Harvard Medical School More Information headache Publications Stoll AL, Severus WE, Freeman MP, headache Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial.
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